November 17, 2011International Journal of Clinical Practice
Differences between South Asians and White Europeans in five year outcome following percutaneous coronary intervention
Key result
South Asian patients had a significantly higher rate of long-term target lesion revascularization compared to White Europeans following PCI (18.4% vs 6.6%; OR 2.83; 95% CI 1.87-4.29; P<0.0001).
Why the study?
Does South Asian ethnicity compared to White European ethnicity affect the rates of target lesion revascularisation and total mortality following percutaneous coronary intervention?
Population
1,158 patients admitted for elective or urgent percutaneous coronary intervention to de novo lesions.
Comparison
South Asian ethnicity (exposure) vs White European ethnicity
Design
Cohort
Follow-up
median 54 months (IQR 47-65)
Authors
Discussion
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Overview
South Asian ethnicity was associated with higher TLR post-PCI; leaves open whether ethnicity-specific strategies are warranted pending prospective validation.
Study Design
Type
Cohort (n=1,158)
Structured PICO
Does South Asian ethnicity compared to White European ethnicity affect the rates of target lesion revascularisation and total mortality following percutaneous coronary intervention?
P
Population
1,158 South Asian and White European patients admitted for elective or urgent PCI to de novo lesions, followed for a median of 54 months.
E
Exposure
South Asian ethnicity (exposure)
C
Comparator
White European ethnicity
O
Outcome
Target lesion revascularisation (TLR) and total mortalityhard clinical
Main Result
Odds Ratio: 2.83 (95% CI 1.87–4.29)
Absolute Event Rate: 18.4% vs 6.6%
p-value: p=<0.0001
South Asian patients undergoing PCI have a significantly higher risk of target lesion revascularization compared to White Europeans, despite similar long-term mortality.
Cite This Study
Toor et al. (2011) conducted a cohort in Patients admitted for elective or urgent PCI to de novo lesions (n=1,158). South Asian ethnicity vs. White European ethnicity was evaluated on Target lesion revascularisation (TLR) (OR 2.83, 95% CI 1.87-4.29, p=<0.0001). South Asian patients had a significantly higher rate of long-term target lesion revascularization compared to White Europeans following PCI (18.4% vs 6.6%; OR 2.83; 95% CI 1.87-4.29; P<0.0001).