Rheumatoid arthritis patients are twice as likely to experience sudden cardiac death compared with non-RA subjects, highlighting the pro-arrhythmogenic role of chronic systemic inflammation.
Rheumatoid arthritis (RA) is a chronic immuno-mediated disease primarily affecting the joints, characterized by persistent high-grade systemic inflammation. Cardiovascular morbidity and mortality are significantly increased in RA, with >50% of premature deaths attributable to cardiovascular disease. In particular, RA patients were twice as likely to experience sudden cardiac death compared with non-RA subjects, pointing to an increased propensity to develop malignant ventricular arrhythmias. Indeed, ventricular repolarization (QT interval) abnormalities and cardiovascular autonomic nervous system dysfunction, representing two well-recognized risk factors for life-threatening ventricular arrhythmias in the general population, are commonly observed in RA. Moreover, large population-based studies seem to indicate that also the prevalence of atrial fibrillation is significantly higher in RA subjects than in the general population, thus suggesting that these patients are characterized by an abnormal diffuse myocardial electrical instability. Although the underlying mechanisms accounting for the pro-arrhythmogenic substrate in RA are probably intricate, the leading role seems to be played by chronic systemic inflammatory activation, able to promote arrhythmias both indirectly, by accelerating the development of ischaemic heart disease and congestive heart failure, and directly, by affecting cardiac electrophysiology. In this integrated mechanistic view, lowering the inflammatory burden through an increasingly tight control of disease activity may represent the most effective intervention to reduce arrhythmic risk in these patients. Intriguingly, these considerations could be more generally applicable to all the diseases characterized by chronic systemic inflammation, and could help elucidate the link between low-grade chronic inflammation and arrhythmic risk in the general population.
“QTc prolongation, a well-established predictor of fatal ventricular arrhythmias and sudden cardiac death (SCD) in the general population, is a common clinical feature in CIA, also correlating with disease activity and inflammatory markers. Accordingly, increasing evidence indicates that in these patients systemic inflammation can increase myocardial electric instability by both accelerating structural cardiovascular disease development and directly affecting cardiac electrophysiology.”
Lazzerini et al. (Wed,) conducted a review in Rheumatoid arthritis. Rheumatoid arthritis vs. Non-RA subjects was evaluated. Rheumatoid arthritis patients are twice as likely to experience sudden cardiac death compared with non-RA subjects, highlighting the pro-arrhythmogenic role of chronic systemic inflammation.