Key result
Tropomyosin isoform diversity in multicellular animals is generated by specific genetic mechanisms that hold potential significance for cellular function.
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Design
Review
May inform cardiac myofilament regulation; leaves open functional validation in disease models.
The tropomyosins are a family of actin filament binding proteins. In multicellular animals, they exhibit extensive cell type specific isoform diversity. In this essay we discuss the genetic mechanisms by which this diversity is generated and its possible significance to cellular function.
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Lees‐Miller et al. (1991) studied this question. Tropomyosin isoform diversity in multicellular animals is generated by specific genetic mechanisms that hold potential significance for cellular function.
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