Variation of the Glycosylation Pattern in MUC1 Glycopeptide BSA Vaccines and Its Influence on the Immune Response

A shot in the arm for anticancer vaccines: Synthetic MUC1 glycopeptides bearing the STn and 2,6-ST antigens were conjugated covalently to BSA (see scheme). The obtained synthetic vaccines induced very strong immune responses in Balb/c mice. Predominant IgG isotype antibodies were induced. The antibodies exhibited strong binding to breast cancer cells of the MCF-7 cell line. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.