Key result
68Ga-PSMA PET/CT demonstrated false-positive radiotracer uptake in the right cerebellar hemisphere corresponding to a subacute cerebellar infarction, mimicking metastasis.
Case Report (n=1)
Subacute cerebellar infarction can cause false-positive radiotracer uptake on 68Ga-PSMA PET/CT, mimicking metastasis.
Warrants caution interpreting PSMA-avid cerebellar lesions in prostate cancer; single case leaves prevalence open.
We report a case of subacute cerebellar infarction mimicking metastasis on prostate-specific membrane antigen (PSMA) PET/CT. A 77-year-old man with prostate cancer treated with androgen deprivation therapy and radiotherapy with rising prostate-specific antigen was referred for Ga-PSMA PET/CT. Apart from PSMA-expressing tumor of the left prostate, PSMA PET/CT demonstrated radiotracer uptake in the right cerebellar hemisphere, corresponding to a site of subacute infarction demonstrated on an MRI of the brain performed 35 days previously. As cerebellar infarcts are considerably less common than cerebral infarcts, they may not be anticipated as a potential cause for false-positive radiotracer uptake on PSMA PET.
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Oh et al. (2017) conducted a case report in Prostate cancer and subacute cerebellar infarction (n=1). 68Ga-PSMA PET/CT was evaluated on Radiotracer uptake on PSMA PET/CT. 68Ga-PSMA PET/CT demonstrated false-positive radiotracer uptake in the right cerebellar hemisphere corresponding to a subacute cerebellar infarction, mimicking metastasis.
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