A De Ritis ratio >1.30 at hospital admission independently predicted a significantly increased risk of 1-year major adverse cardiovascular events (HR 2.362) in elderly patients with acute decompensated heart failure.
Cohort (n=249)
No
Does an elevated De Ritis ratio predict 1-year major adverse cardiovascular events in elderly patients hospitalized with acute decompensated heart failure?
An elevated De Ritis ratio (>1.30) at admission is a simple, accessible, and independent predictor of 1-year major adverse cardiovascular events in elderly patients hospitalized with acute decompensated heart failure.
Hazard Ratio: 2.362 (95% CI 1.536–3.634)
p-value: p=<0.001
Abstract Background The De Ritis ratio, derived from serum aspartate aminotransferase and alanine aminotransferase levels, has shown prognostic value in cardiovascular diseases. Its role in elderly patients hospitalized with acute decompensated heart failure (ADHF) remains uncertain. Objectives To evaluate the prognostic value of the De Ritis ratio for 1-year major adverse cardiovascular events (MACEs) in elderly patients with ADHF. Methods A single-center, prospective cohort of 249 patients aged ≥65 years (median age 78, 53.8% female) hospitalized with ADHF was enrolled. Patients were categorized into tertiles by De Ritis ratio: 1.30 independently predicted outcomes (hazard ratio: 2.362; 95% CI: 1.536-3.634; P < 0.001). Conclusions An elevated De Ritis ratio is an independent predictor of 1-year MACEs in elderly patients with ADHF. This simple, accessible biomarker may aid clinical risk stratification.
Hoang et al. (Wed,) conducted a cohort in Acute decompensated heart failure (n=249). De Ritis ratio >1.30 vs. De Ritis ratio ≤1.30 was evaluated on 1-year major adverse cardiovascular events (MACEs) (HR 2.362, 95% CI 1.536-3.634, p=<0.001). A De Ritis ratio >1.30 at hospital admission independently predicted a significantly increased risk of 1-year major adverse cardiovascular events (HR 2.362) in elderly patients with acute decompensated heart failure.