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Acute lymphoblastic leukemia (ALL) is the most prevalent cancer among children and adolescents in the United States, representing 20% of all cancers diagnosed in persons aged 3,000 new cases each year (1). Past studies reported increasing trends of ALL overall and among Hispanics, but these represented 28% of the U.S. population and did not provide state-based estimates (1-3). To describe U.S. ALL incidence rates and trends among persons aged <20 years during 2001-2014, CDC analyzed rigorous data (based on established publication criteria) from the United States Cancer Statistics data set, which includes incidence data on approximately 15,000 new cases per year of all types of invasive cancer among children and adolescents aged <20 years (4). The data set represented 98% of the U.S. population during the study period. Overall incidence of pediatric ALL during 2001-2014 was 34.0 cases per 1 million persons and among all racial/ethnic groups was highest among Hispanics (42.9 per 1 million). Both overall and among Hispanics, pediatric ALL incidence increased during 2001-2008 and remained stable during 2008-2014. ALL incidence was higher in the West than in any other U.S. Census region. Statespecific data indicated that the highest rates of pediatric ALL incidence were in California, New Mexico, and Vermont. These demographic and geographic ALL incidence data might better inform public health interventions targeting the following areas: exposures to recognized risk factors for leukemia; ALL treatment, including clinical trial enrollment; survivorship care planning; and studies designed to understand the factors affecting changes in pediatric cancer incidence. The United States Cancer Statistics data set includes cancer incidence data from CDC's National Program of Cancer Registries and the National Cancer Institute's Surveillance, Epidemiology, and End Results program (4). Data on new cases of cancer diagnosed during 2001-2014 were obtained from population-based cancer registries affiliated with the National Program of Cancer Registries or Surveillance, Epidemiology, and End Results programs. Incidence data for all registries except the District of Colombia, Mississippi, and Nevada met United States Cancer Statistics publication criteria during 2001-2014, and represented 98% of the U.S population.* This * Cancer registries' incidence data met the following five United States Cancer
Siegel et al. (Thu,) studied this question.