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June 3, 2020Science Translational Medicine

Gene editing to induce FOXP3 expression in human CD4 ⁺ T cells leads to a stable regulatory phenotype and function

Yuchi Honaker Nicholas Hubbard Yufei Xiang Logan Fisher David Hagin Karen Sommer Yumei Song Soo Jung Yang Christina Lopez Tori Tappen Elizabeth M. Dam Iram Khan Malika Hale Jane H. Buckner Andrew M. Scharenberg Troy R. Torgerson David J. Rawlings

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Abstract

Gene editing to insert a strong promoter upstream of endogenous FOXP3 conferred T reg -like properties and functions to primary human CD4 + T cells.

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Honaker et al. (2020) studied this question.

synapsesocial.com/papers/6a3181cf34304528d81cd003 https://doi.org/10.1126/scitranslmed.aay6422

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