Key result
Recombinant PEDV strain CH/HLJ/18 causes 100% mortality and severe diarrhea in newborn piglets.
Why the study?
Porcine epidemic diarrhea virus distribution and pathogenicity have increased in China, requiring a better understanding of its genetic evolution and diversity for vaccine development, prevention, and treatment.
Population
Newborn piglets and Vero cell cultures
Comparison
Inoculation with PEDV strain CH/HLJ/18
Design
In vitro isolation, phylogenetic analysis, and in vivo animal inoculation study
Follow-up
7 d
Authors
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Supports PEDV genomic surveillance in China; leaves open functional and vaccine implications for GII-a strains.
Absolute Event Rate: 100% vs 0%
The isolation and characterization of the highly pathogenic recombinant PEDV strain CH/HLJ/18 provides insights into the genetic evolution of PEDV in China.
Guo et al. (2024) studied Porcine epidemic diarrhea (n=8). PEDV CH/HLJ/18 strain vs. Sham-inoculated control (5 mL M199) was evaluated on Mortality within 7 days. The newly isolated recombinant PEDV strain CH/HLJ/18 was highly pathogenic, causing severe watery diarrhea and 100% mortality within 7 days in inoculated newborn piglets.
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