Key result
Flecainide concentration was highest in the lungs (143 micrograms/g wet tissue), followed by the liver, kidney, and heart, with the lowest concentration in adipose tissue.
Why the study?
What is the tissue distribution of flecainide in a human patient on chronic therapy?
Case Report (n=1)
What is the tissue distribution of flecainide in a human patient on chronic therapy?
Flecainide accumulates most highly in the lungs, followed by the liver, kidney, and heart, which may provide insight into its therapeutic and adverse effects.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for flecainide distribution; should not change practice or guide dosing without further study.
The distribution of antiarrhythmic drugs in human tissues may yield a better understanding of their therapeutic action and side effects. We report tissue distribution of flecainide in a patient who died suddenly while being treated chronically with the drug. Lungs showed the highest concentration of flecainide (143 micrograms g-1 wet tissue); liver, kidney and heart, in decreasing order, have good affinity for the drug. Flecainide was present also in the central nervous system in lower concentrations. The lowest concentration was found in the adipose tissue.
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Latini et al. (1987) conducted a case report in Sudden death (n=1). Flecainide was evaluated on Tissue distribution of flecainide. Flecainide concentration was highest in the lungs (143 micrograms/g wet tissue), followed by the liver, kidney, and heart, with the lowest concentration in adipose tissue.
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