January 1, 2023International Journal of Biological Sciences74 citationsOpen Access

CENPA functions as a transcriptional regulator to promote hepatocellular carcinoma progression via cooperating with YY1

JLJingyu LiaoSun Yat-sen University ZCZeyu ChenTongji University RCRuizhi ChangTongji Hospital

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Abstract

. Mechanistically, CENPA transcriptionally activated and cooperated with YY1 to drive the expression of cyclin D1 (CCND1) and neuropilin 2 (NRP2). Moreover, we identified that CENPA can be lactylated at lysine 124 (K124). The lactylation of CENPA at K124 promotes CENPA activation, leading to enhanced expression of its target genes. In summary, CENPA function as a transcriptional regulator to promote HCC via cooperating with YY1. Targeting the CENPA-YY1-CCND1/NRP2 axis may provide candidate therapeutic targets for HCC.

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Liao et al. (Sun,) studied this question.

synapsesocial.com/papers/6a31f25fe95744b140e5a0b3 https://doi.org/https://doi.org/10.7150/ijbs.85656

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