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April 28, 2017Journal of Biological ChemistryOpen Access

Reactive oxygen species production induced by pore opening in cardiac mitochondria: The role of complex II

Paavo Kôrge Scott John Guillaume Calmettes James N. Weiss

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Abstract

is reduced. Because ischemia is known to inhibit complexes II and III and increase matrix succinate/fumarate levels, we hypothesize that by allowing dicarboxylate efflux from the matrix, PTP opening during reperfusion may activate sustained ROS production by this mechanism after RET-driven ROS production has ceased.

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Kôrge et al. (2017) studied this question.

synapsesocial.com/papers/6a31f9d5e747690588e447c9 https://doi.org/10.1074/jbc.m116.768325

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