Why the study?
Does a single session of high-intensity interval exercise compared to moderate-intensity continuous exercise alter transcriptional changes in subcutaneous abdominal adipose tissue in adults with obesity?
Does a single session of high-intensity interval exercise compared to moderate-intensity continuous exercise alter transcriptional changes in subcutaneous abdominal adipose tissue in adults with obesity?
A single session of either high-intensity or moderate-intensity exercise alters the adipose tissue transcriptome 1 hour post-exercise, upregulating inflammation and downregulating metabolism gene sets.
Acute adipose transcriptomic shifts after exercise warrant no practice change in obesity; leaves open their long-term metabolic implications.
This study compared the effects of a single session of high-intensity interval exercise versus moderate-intensity continuous exercise on transcriptional changes in subcutaneous abdominal adipose tissue collected from adults with obesity. Our novel findings indicate exercise upregulated inflammation-related gene sets, while it downregulated metabolism-related gene sets - after both high-intensity and moderate-intensity exercise. These data suggest exercise can alter the adipose tissue transcriptome 1 h after exercise in ways that may impact inflammation and metabolism.
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Ludzki et al. (2021) studied this question.
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