What question did this study set out to answer?

To investigate the role of secretory leukocyte protease inhibitor (SLPI) in the production of monocyte-derived matrix metalloproteinases.

Secretory leukocyte protease inhibitor suppresses the production of monocyte prostaglandin H synthase-2, prostaglandin E2, and matrix metalloproteinases.

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To investigate the role of secretory leukocyte protease inhibitor (SLPI) in the production of monocyte-derived matrix metalloproteinases.
Monocytes were stimulated with concanavalin A or LPS and pre-treated with SLPI.
Effects on prostaglandin H synthase-2 and MMP productions were measured at various SLPI concentrations.
Cytokine production was assessed for changes in TNF-alpha and IL-10 levels.
SLPI significantly inhibited prostaglandin H synthase-2 with 0.1 microg/ml showing decreased levels of PGE2 (p<0.01).
Suppression of MMP-1 and MMP-9 was achieved, reversible by PGE2 or Bt2cAMP.
SLPI's inhibitory effect was independent of its antiprotease activity and did not affect monokine levels.

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Randomized trial examines SLPI's effects on MMP production in monocytes, highlighting its anti-inflammatory potential.

Zhang et al. (1997) studied this question.

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