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June 17, 2026Allelopathy Journal

From plant flavonoids to drug candidate: Solubility enhancement of Kaempferol

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Authors

NMNeeti MishraRWRamanpreet WaliaRMRakhi Mishra

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Overview

Randomized trial demonstrates improved solubility of kaempferol prodrugs, highlighting their therapeutic potential.

Key Points

  • The aim is to develop kaempferol prodrugs to enhance solubility and therapeutic efficacy.
  • Conjugated hydroxyl groups of kaempferol with carbamate ester–derived promoieties
  • Synthesized novel prodrug derivatives for increased solubility
  • Analyzed solubility and bioavailability compared to native kaempferol.
  • Prodrugs showed significantly increased aqueous solubility compared to kaempferol.
  • The enhanced solubility improved biological and therapeutic efficacy.
  • Findings support the use of N-monosubstituted carbamate esters in prodrug design for plant polyphenols.

Cite This Study

Mishra et al. (2026) studied this question.

synapsesocial.com/papers/6a3238acd50b63ecad20479ehttps://doi.org/10.26651/allelo.j/2026-68-2-1593
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