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This review aims to elucidate the role of retinoic acid signaling in spermatogenesis and its implications for male contraception.

June 17, 2026AnimalsOpen Access

Retinoic Acid Signaling in Male Reproductive Biology: From Germ Cell Regulation to Contraceptive Innovation Within a One Health Framework

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Review explores retinoic acid's role in spermatogenesis, highlighting its potential for male contraception.

This review aims to elucidate the role of retinoic acid signaling in spermatogenesis and its implications for male contraception.
Integrative review of molecular mechanisms involved in retinoic acid signaling and spermatogenesis.
Comparative analysis of retinoic acid pathways in rodent and canine models.
Evaluation of pharmacological interventions affecting spermatogenesis via retinoic acid signaling.
Retinoic acid acts as a master regulator of meiotic initiation and spermatogonial differentiation.
Pharmacological manipulation of retinoic acid signaling can disrupt spermatogenesis in a reversible manner.
Conservation of retinoic acid signaling pathways indicates translational potential for non-hormonal male contraception.

Kasimanickam et al. (2026) studied this question.

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