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June 17, 2026Journal of Clinical InvestigationOpen Access

Rewriting the cancer proteome: targeting selective translation as a therapeutic frontier

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Authors

DRDavide Ruggero

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Overview

Randomized trial finds targeting selective translation rewires cancer identity, indicating new treatment strategies.

Key Points

  • This research aims to explore how targeting selective translation can disrupt cancer-specific protein generation.
  • Pharmacologic inhibition of eIF4E cap binding was employed.
  • The effects on prostate cancer translatome were analyzed for basal keratin and luminal features.
  • Sensitivity to hormone therapy was evaluated post-treatment.
  • Inhibition of eIF4E suppressed basal keratin translation while promoting luminal features.
  • The treatment renewed sensitivity to hormone therapy in prostate cancer cells.
  • Illustrated that selective translation aids in maintaining lineage plasticity and therapeutic resistance.

Cite This Study

Davide Ruggero (2026) studied this question.

synapsesocial.com/papers/6a3238e2d50b63ecad20497dhttps://doi.org/10.1172/jci207335
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