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The aim is to explore recent advancements in the synthesis of quinoline derivatives using sustainable catalytic approaches.

June 17, 2026MoleculesOpen Access

Recent Advances in Quinoline Synthesis: Sustainable Catalytic Strategies and Emerging Methodologies

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Review summarizes new catalytic methods for quinoline synthesis, indicating progress towards sustainable practices.

The aim is to explore recent advancements in the synthesis of quinoline derivatives using sustainable catalytic approaches.
Review of classical transformations such as Friedländer, Skraup, and Povarov reactions.
Discussion of homogeneous and heterogeneous catalytic systems using transition metals.
Evaluation of sustainable practices like solvent-free processes and microwave-assisted synthesis.
Enhanced reaction efficiency and selectivity in quinoline synthesis are achieved through modern catalytic strategies.
Emerging methodologies demonstrate reduced waste generation and energy consumption.
Identification of opportunities for next-generation catalytic systems in quinoline construction.

López‐Coca et al. (2026) studied this question.

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