Synthesis, Characterization, and Photobiological Evaluation of Novel Acetyl‐Glycosylated Corroles as Potential Photosensitizers

This work reports the synthesis, structural characterization, and photophysical and electrochemical evaluation of a novel series of mono‐(acetyl‐glycosylated) free‐base corroles. The molecules were prepared using classical Gryko methodologies, yielding four new acetyl‐glycosylated derivatives alongside a nonglycosylated reference compound. A complete spectroscopic and analytical characterization was performed, including absorption, steady‐state, and time‐resolved fluorescence, and electrochemical studies. Detailed analysis of the singlet and triplet excited states, supported by DFT calculations and natural transition orbital (NTO) analysis, confirmed the nature of the electronic transitions and provided insight into excited‐state geometries. Furthermore, the derivatives were evaluated for key photobiological properties: all compounds demonstrated efficient singlet oxygen ( 1 O 2 ) generation, and, in preliminary membrane‐model assays, an ability to interact with biological targets. The overall data confirm that these acetyl‐glycosylated corroles retain potent photosensitizing capabilities, establishing their promising potential for applications such as photodynamic therapy (PDT).