What question did this study set out to answer?

The research aims to assess how high-protein diets impact renal function and body composition in adults without chronic kidney disease.

Effects of High‐Protein Diets on Renal Function and Body Composition in Adults Without Chronic Kidney Disease: A Systematic Review and Meta‐Analysis of Randomised Trials

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Systematic review evaluates renal function and body composition effects of high-protein diets in adults, suggesting caution.

The research aims to assess how high-protein diets impact renal function and body composition in adults without chronic kidney disease.
Systematic search of PubMed, Embase, and Cochrane Central Register for randomized controlled trials comparing high-protein and NPL diets.
Primary outcomes included estimated glomerular filtration rate and serum creatinine; secondary outcomes were body fat percentage, total fat mass, and fat-free mass.
Random-effects meta-analysis was performed with assessment of bias using the Cochrane RoB 2 tool and evidence certainty evaluated with GRADE.
High-protein diets increased eGFR (standardised mean difference 0.39, 95% CI 0.09–0.69; I 2 = 74.9%).
No significant change in serum creatinine (standardised mean difference 0.08, 95% CI −0.09 to 0.25; I 2 = 20.8%) across trials.
High-protein diets reduced body fat percentage and total fat mass but had no significant effect on fat-free mass.

Silva et al. (2026) studied this question.

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