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This study aims to evaluate the effectiveness of bacteriophages in reducing Salmonella colonization in broiler chicks.

June 17, 2026Poultry ScienceOpen Access

Effect of in ovo and oral bacteriophage administration on intestinal Salmonella colonization in Cobb broiler chicks

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Randomized trial evaluates bacteriophage efficacy to reduce Salmonella in broiler chicks, suggesting a potential antibiotic alternative.

This study aims to evaluate the effectiveness of bacteriophages in reducing Salmonella colonization in broiler chicks.
Sixty Cobb broiler chicks were divided into six groups (n=10 each) for phage treatments: in ovo and oral administration at different MOIs.
Fecal shedding of Salmonella Typhimurium and cecal bacterial counts were measured post-treatment.
Histopathology assessed intestinal damage in phage-treated and challenged control birds.
Oral administration at MOI 1 led to the greatest reduction in bacterial shedding compared to controls.
In ovo administration at MOI 2 showed sustained suppression of S. Typhimurium colonization.
All phage-treated groups had significantly lower cecal bacterial counts and reduced intestinal lesions compared to the challenged control.

KawathekarS et al. (2026) studied this question.

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