Two novel polysaccharides from Spatholobus uniauritus: Extract optimization, purification, structural characterization, hypoglycemic and immunomodulatory effects

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The study aimed to optimize the extraction and characterize novel polysaccharides from Spatholobus uniauritus, assessing their biological effects.
Optimized hot water extraction parameters for polysaccharides from S. uniauritus
Isolated and characterized two polysaccharides (SUW−1 and SUW−2) using structural analysis
Evaluated hypoglycemic and immunomodulatory effects in various cell lines including L02, 3T3-L1, and RAW264.7.
SUW−1 (4.57 kDa) increased glucose uptake in L02 and 3T3-L1 cells
SUW−2 (1.96 kDa) enhanced glucose uptake in C2C12 and L02 cells
Both polysaccharides stimulated macrophage functions, with SUW−1 showing superior immunostimulatory activity.

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Evaluates hypoglycemic and immunomodulatory effects of two polysaccharides in cell models, suggesting potential therapeutic applications.

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Wang et al. (2026) studied this question.

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