Flowzonolysis: Continuous Oxidative Ozonolysis of Algae‐Derived Palmitoleic Acid for the Synthesis of Azelaic Acid

The growing demand for bio‐based diacids has intensified the need for safer and more sustainable oxidative cleavage methods with renewable feedstocks. Azelaic acid is a valuable platform chemical, yet conventional ozonolysis routes from fatty acids rely on complicated multi‐step syntheses and often require additional reagents, contributing to increased waste and safety concerns. Here, we report on flowzonolysis, a continuous oxidative ozonolysis method, to afford azelaic acid from algae‐based palmitoleic acid. This fully continuous process integrates alkene cleavage and oxidative conversion without isolation of reactive intermediates, minimizing the use of supplemental oxidants and aligning with green chemistry principles such as improved atom economy, reduced auxiliary reagent use, and utilization of renewable feedstocks.