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June 17, 2026Cephalalgia

Beyond headache: Cognitive improvement in patients with migraine responding to anti-CGRP monoclonal antibodies or botulinum toxin

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Authors

IMIsabel Pavão MartinsMTMariana Costa TaveiraMCMaria Couto

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Overview

Randomized trial evaluates cognitive performance improvement in migraine patients receiving anti-CGRP or botulinum toxin, indicating potential cognitive benefits of effective treatment.

Key Points

  • Evaluate cognitive performance improvement in migraine patients treated with anti-CGRP mAbs or botulinum toxin and compare outcomes between responders and non-responders.
  • Multi-center prospective longitudinal study of migraine patients receiving either mAbs or BoNT.
  • Cognitive evaluations were performed at baseline and after 3-6 months of treatment, assessing multiple cognitive domains.
  • Treatment response was defined by a significant reduction in monthly moderate-to-severe headache days.
  • Among 90 patients, 52.2% responded to treatment, with a higher executive function improvement in responders than non-responders (p<0.05).
  • Executive function scores improved significantly regardless of treatment type but were not correlated with headache reduction.
  • No significant cognitive differences were found in episodic memory, language, or processing speed between responders and non-responders.

Cite This Study

Martins et al. (2026) studied this question.

synapsesocial.com/papers/6a323b4cd50b63ecad205f2ahttps://doi.org/10.1177/03331024261458424
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