PulseTrendingJournal ClubResearchersJournalsExplore
Instagram
HomeTrendingJournal ClubExplore
Synapse
⌘+K
Synapse
June 17, 2026Journal of Clinical MedicineOpen Access

Integrated Multimodal Critical Care Ultrasound for Mechanism-Based Prediction of Weaning Failure: A Prospective Pilot Study

View Full Paper
Ask AI
Bookmark
Share

Authors

ŞAŞule AsriFSFerhat SoykanMAMustafa Ay

Discussion

Loading...

Member takes

Overview

Prospective pilot study evaluates multimodal ultrasound for predicting weaning failure in ventilated patients, suggesting new assessment strategies.

Key Points

  • This study aims to assess whether a multimodal ultrasound approach can enhance the prediction of weaning failure during mechanical ventilation.
  • Prospective pilot observational study with adult patients on mechanical ventilation and preserved left ventricular function.
  • Multimodal ultrasound assessment included transthoracic echocardiography, lung ultrasound, diaphragmatic ultrasound, and venous excess ultrasound.
  • Primary outcome was a composite of spontaneous breathing trial failure or reintubation within 48 hours.
  • 27 patients were studied; 8 (29.6%) experienced extubation failure.
  • Respiratory system compliance associated with extubation failure (AUC 0.806, cutoff ≤ 45 mL/cmH2O, sensitivity 88%, specificity 74%).
  • Diaphragm excursion was lower in the failure group (p = 0.042), showing significant predictive value (AUC 0.750, cutoff ≤ 24 mm, sensitivity 100%, specificity 58%).

Cite This Study

Asri et al. (2026) studied this question.

synapsesocial.com/papers/6a323b8cd50b63ecad206110https://doi.org/10.3390/jcm15124648
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prediction of weaning outcomes from mechanical ventilation in critically ill patients based on the combination of ultrasound parameters of the heart, lung, and diaphragm: a prospective observational cohort study2025
  2. 2The impact of heart, lung and diaphragmatic ultrasound on prediction of failed extubation from mechanical ventilation in critically ill patients.2024
  3. 3Integrated comprehensive assessment for predicting weaning success in difficult-to-wean critically ill patients: the WEAN-US study2026 · 1 citations
  4. 4Combined cardiac, lung, and diaphragm ultrasound for predicting weaning failure during spontaneous breathing trial2024 · 19 citations
  5. 5Beyond the Spontaneous Breathing Trial: Echocardiographic and Integrated Ultrasound Assessment During Weaning from Mechanical Ventilation2026