This review explores macrophage plasticity in disease contexts, highlighting potential therapeutic strategies.
Key Points
This review aims to explore the plasticity of macrophages and how different environments influence their phenotypes and functions across various diseases.
Comprehensive review of molecular pathways influencing macrophage identity, including TLR signaling and metabolic rewiring.
Analysis of circulating monocyte subsets contributing to macrophage diversity in different diseases.
Discussion of therapeutic strategies such as macrophage reprogramming and CAR-M cell therapies.
Demonstrated that macrophage phenotypes vary significantly across disease contexts, affecting immune responses differently.
Identified soluble markers like sCD163 and sCD14 as promising biomarkers for disease activity and prognosis.
Highlighted the importance of high-dimensional flow cytometry in profiling macrophage characteristics and functions.