Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 27, 2026MedCommOpen Access

Macrophage: Biological Functions, Diseases, and Therapeutic Targets

View Full Paper
Ask AI
Bookmark
Share

Authors

BSBihang SunLWLiling WenSTShiyun Tang

Discussion

Loading...

Member takes

Overview

Review evaluates macrophage roles in disease and potential therapies to restore immune balance.

Key Points

  • This review examines macrophage functions, their roles in disease, and therapeutic strategies to restore balance.
  • Systematic review of macrophage plasticity and polarization imbalance
  • Evaluation of existing and emerging macrophage-directed interventions
  • Analysis of translational bottlenecks using single-cell multi-omics and humanized models
  • Identified pathogenic subset-specific markers are lacking for effective therapy
  • Developed insights into how dynamic biomarkers can help overcome clinical translation hurdles
  • Proposed precision immunotherapy frameworks to restore M1/M2 balance across diseases

Cite This Study

Sun et al. (2026) studied this question.

synapsesocial.com/papers/6a6700af40bca442e0d4a916https://doi.org/10.1002/mco2.70883
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Macrophages: Subtypes, Distribution, Polarization, Immunomodulatory Functions, and Therapeutics2025 · 75 citations
  2. 2Macrophage Plasticity: Phenotypic and Functional Profiles Across Pathological Microenvironments2026
  3. 3Macrophage polarization in inflammatory regulation: molecular mechanisms, therapeutic targets, and translational challenges2026 · 9 citations
  4. 4Macrophages: Balancing Inflammation and Homeostasis in Health and Disease2024 · 6 citations
  5. 5Macrophage plasticity and polarization: in vivo veritas2012 · 6,494 citations