Key result
The C-reactive protein-triglyceride-glucose index (CTI) was independently associated with long-term MACCE risk in ACS patients.
Why the study?
The C-reactive protein-triglyceride-glucose index (CTI) combines inflammation with metabolic status, but its prognostic value for long-term MACCE in patients with ACS remained unclear.
Does the C-reactive protein–triglyceride-glucose index (CTI) improve the prediction of long-term major adverse cardiovascular and cerebrovascular events (MACCE) compared to the TyG index or hs-CRP alone in patients with acute coronary syndrome?
Cohort (n=9,131)
Outcome events were adjudicated by trained investigators who were blinded to biomarker data
No
Does the C-reactive protein–triglyceride-glucose index (CTI) improve the prediction of long-term major adverse cardiovascular and cerebrovascular events (MACCE) compared to the TyG index or hs-CRP alone in patients with acute coronary syndrome?
The composite C-reactive protein–triglyceride-glucose index (CTI) is independently associated with long-term MACCE in patients with ACS and provides modest incremental prognostic value over the TyG index or hs-CRP alone.
Answers are grounded in this paper and cite their sources.
May refine ACS risk stratification; leaves open incremental value over TyG or hs-CRP in prospective trials.
The C‐reactive protein–triglyceride‐glucose index (CTI) combines inflammation with metabolic status, but its prognostic value in patients with acute coronary syndrome (ACS) remains unclear. We studied 9131 patients with ACS admitted between 2021 and 2024 to examine the associations of CTI, the triglyceride‐glucose (TyG) index, and high‐sensitivity C‐reactive protein (hs‐CRP) with long‐term major adverse cardiovascular and cerebrovascular events (MACCE). Cox regression models, restricted cubic spline analyses, and predictive performance analyses were performed. After a median follow‐up of 707 days, 801 patients developed MACCE. In fully adjusted models, CTI (hazard ratio [HR] = 1.248, 95% CI: 1.150–1.355), the TyG index (HR = 1.235, 95% CI: 1.115–1.367), and hs‐CRP (HR = 1.031, 95% CI: 1.018–1.047) were all significantly associated with MACCE risk. Patients in the highest CTI quartile had a greater risk of MACCE than those in the lowest quartile (HR = 1.651, 95% CI: 1.333–2.045). Restricted cubic spline analyses showed positive associations without significant nonlinearity. CTI yielded a numerically higher area under the curve (AUC) than the TyG index and hs‐CRP, although the improvement was modest. These findings suggest that CTI may provide supplementary metabolic‐inflammatory information for MACCE risk assessment in ACS, but external validation is needed.
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Wang et al. (2026) conducted a cohort in Acute coronary syndrome (ACS) (n=9,131). C-reactive protein-triglyceride-glucose index (CTI) vs. Lowest CTI quartile (Q1 < 8.460) and individual biomarkers (triglyceride-glucose [TyG] index and hs-CRP) was evaluated on Major adverse cardiovascular and cerebrovascular events (MACCE: composite of all-cause death, nonfatal myocardial infarction, nonfatal stroke, and unplanned revascularization) (HR 1.248, 95% CI 1.150-1.355, p=<0.001). The C-reactive protein-triglyceride-glucose index (CTI) was independently associated with long-term MACCE risk in ACS patients.
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