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June 17, 2026Advanced ScienceOpen Access

A Single‐Cell Transcriptomic Atlas of the Ovine Rumen Microbiome Characterizes Lineage‐Specific Metabolic Shifts Associated with Host Heat Tolerance

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Authors

SZSanbao ZhangFirst Affiliated Hospital Zhejiang UniversityQJQinyang JiangGuangxi UniversityJMJunjie MaAnhui University of Science and Technology

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Implication

Randomized trial characterizes metabolic shifts in sheep microbiomes, suggesting links to heat tolerance.

Key Points

  • The study aims to map the ovine rumen microbiome through single-cell transcriptomics to understand metabolic adaptations related to host heat tolerance.
  • Developed a 25-minute enzymatic lysis strategy using smRandom-seq for single-cell resolution.
  • Profiled 60,748 cells across 21 samples to resolve transcriptional states of 213 genera and 662 species.
  • Utilized unsupervised clustering to identify functional clusters within the microbiome.
  • Achieved a 0.303% recovery rate of methanogenic archaea.
  • Identified a glycolytic metabolic shift in Anaerovibrio lipolyticus indicating a 'nutritional sparing' effect.
  • Demonstrated that host thermal adaptation is linked with rapid activation of energy-metabolism clusters.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a323bbcd50b63ecad2062bchttps://doi.org/10.1002/advs.76152
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