Network meta-analysis of bisphosphonates in the treatment of bone metastases from breast cancer

Li-Wen Zhang; An Huang; Hongfang Ma; Jun Shen

doi:10.5414/cp204946

June 15, 2026International Journal of Clinical Pharmacology and Therapeutics

Network meta-analysis of bisphosphonates in the treatment of bone metastases from breast cancer

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Key Points

This research evaluates the effectiveness and safety of bisphosphonates for reducing skeletal complications in breast cancer bone metastases.
Conducted a network meta-analysis of randomized controlled trials (RCTs)
Retrieved data from PubMed, Cochrane, and Embase databases until January 2025
Performed statistical analyses using Stata software
Clodronate was most effective in reducing pathological fractures (OR = -1.41, 95% CI: -2.78 to -0.04) compared to pamidronate and (OR = -1.44, 95% CI: -2.85 to -0.04) compared to zoledronate.
Zoledronate was more effective than clodronate and pamidronate in reducing hypercalcemia, but not statistically significant (p > 0.05).
Ibandronate had fewer adverse reactions than clodronate and zoledronate, showing a significant difference (OR = -1.14, 95% CI: -1.99 to -0.28) between ibandronate and zoledronate.

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Implication

Randomized trial evaluates efficacy and safety of bisphosphonates in treating bone metastases from breast cancer, suggesting optimal treatment options.

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a323bf5d50b63ecad206476 https://doi.org/10.5414/cp204946

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Network meta-analysis of bisphosphonates in the treatment of bone metastases from breast cancer

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Network meta-analysis of bisphosphonates in the treatment of bone metastases from breast cancer

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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