Opportunities and challenges for analytical chemists: organ-on-chip devices as new approach methods (NAMs) for identifying potential toxins

Evan Huang; Jose A. Nolasco; Sarina J. Jones; Matthew R. Lockett

doi:10.1039/d5an01351h

January 1, 2026The AnalystOpen Access

Opportunities and challenges for analytical chemists: organ-on-chip devices as new approach methods (NAMs) for identifying potential toxins

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Key Points

This perspective focuses on the advancements needed for organ-on-chip devices as new methods for toxicity assessment.
Discusses key features required for organ-on-chip devices.
Outlines current limitations in assessing drug candidate toxicity.
Examines potential of organ-on-chip technology in toxicology.
Identifies opportunities for integrating organ-on-chip devices in drug development.
Highlights challenges hindering the widespread adoption of these technologies.
Emphasizes the need for further research to validate device efficacy in toxicity assessment.

Implication

Perspective highlights opportunities and challenges for organ-on-chip devices in toxicity assessment, implying a new frontier for analytical chemistry.

Abstract

This perspective outlines and highlights the key features needed to advance organ-on-chip devices as NAMs for assessing the toxicity of new drug candidates and potential toxins.

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Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/6a323bf5d50b63ecad206571 https://doi.org/10.1039/d5an01351h

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Opportunities and challenges for analytical chemists: organ-on-chip devices as new approach methods (NAMs) for identifying potential toxins

Key Points

Implication

Abstract

Discussion

Cite This Study

Opportunities and challenges for analytical chemists: organ-on-chip devices as new approach methods (NAMs) for identifying potential toxins

Key Points

Implication

Abstract

Discussion

Cite This Study

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