A Molecular Theory of Oiling-out during Crystallization

Prem Podupu; Anuoluwaposimi Ijimakinwa; Meenesh R. Singh

doi:10.1039/d6cp00296j

January 1, 2026Physical Chemistry Chemical PhysicsOpen Access

A Molecular Theory of Oiling-out during Crystallization

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Key Points

The research aims to understand the mechanisms of oiling-out during crystallization and its impact on pharmaceutical processes.
Analyzed thermodynamic principles related to liquid-liquid phase separation during crystallization.
Developed a molecular theory to explain the occurrence of oiling-out.
Examined the implications of phase boundaries on crystallization efficiency.
Identified key thermodynamic parameters influencing oiling-out phenomena.
Demonstrated that specific conditions can lead to substantial reductions in crystallization yield and purity.
Proposed strategies to mitigate oiling-out in pharmaceutical applications.

Implication

Uncovers the mechanisms behind oiling-out in crystallization, suggesting solutions for pharmaceutical challenges.

Abstract

Oiling-out, an undesirable liquid-liquid phase separation (LLPS) frequently encountered in pharmaceutical crystallization, poses significant challenges by reducing purity, yield, and process robustness. While macroscopic thermodynamics describes the phase boundaries of...

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Cite This Study

Podupu et al. (2026) studied this question.

synapsesocial.com/papers/6a323cc9d50b63ecad206c49 https://doi.org/10.1039/d6cp00296j

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A Molecular Theory of Oiling-out during Crystallization

Key Points

Implication

Abstract

Discussion

Cite This Study

A Molecular Theory of Oiling-out during Crystallization

Key Points

Implication

Abstract

Discussion

Cite This Study

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