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June 17, 2026CHRISMED Journal of Health and ResearchOpen Access

Etiological Spectrum and Diagnostic Approach in Primary Amenorrhea: Insights from a Case Series of 26 Patients

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Authors

NBNaga BhagyasriPDPrasun DebSNSmitha Nalla

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Overview

Retrospective analysis identifies causes and management of primary amenorrhea, indicating the need for early intervention.

Key Points

  • The aim is to analyze the clinical profiles and diagnostic approaches in patients with primary amenorrhea.
  • Retrospective observational study of 26 cases diagnosed with primary amenorrhea from 2018 to 2023.
  • Data on demographics, clinical features, hormonal assays, imaging findings, and karyotypes were extracted from hospital records.
  • Investigations included hormonal evaluation, pelvic ultrasound, karyotyping, and MRI in selected cases.
  • Gonadal dysfunction was the most common cause (50%), including Turner syndrome (n=6) and 46, XY disorders (n=4).
  • Abnormal karyotypes were found in 8 patients; the management included hormone replacement therapy and gonadectomy when needed.
  • Early diagnosis and a systematic approach improved outcomes for pubertal induction and reproductive health.

Cite This Study

Bhagyasri et al. (2026) studied this question.

synapsesocial.com/papers/6a323cc9d50b63ecad206ddehttps://doi.org/10.4103/cjhr.cjhr_90_25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Girls referred for amenorrhea: analysis of a patient series from a specialist center2024 · 4 citations
  2. 2EVALUATION OF PATIENTS WITH PRIMARY AMENORRHEA: A TERTIARY HEALTHCARE CENTER EXPERIENCE2026
  3. 3Evaluation and Management of Secondary Amenorrhea: A Case Series in a Tertiary Care Centre2024
  4. 4Genetic Causes of Primary Amenorrhea Using Chromosomal Analysis and PCR for SRY Gene2024
  5. 5Primary Amenorrhoea2024