What does this research mean for the field?

Dietary bioactive compounds and nutritional patterns actively regulate the cancer epigenome through mechanisms such as DNA methylation and histone modification, providing a mechanistically coherent basis for personalized nutritional interventions in cancer prevention and precision oncology. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To synthesize evidence on how dietary components affect epigenetic mechanisms relevant to cancer.

June 17, 2026Nutrition & MetabolismOpen Access

The nutrigenomic-epigenetic axis in cancer: from dietary bioactives to precision oncology

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Authors

FBFatemeh BoroomandUniversity of Padua MKMohammad Amin KarimiShahid Beheshti University of Medical Sciences EKElaheh Karimzadeh‐SoureshjaniHamedan University of Medical Sciences

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Implication

Review reveals dietary bioactives influence cancer mechanisms, highlighting nutritional strategies for intervention.

Key Points

To synthesize evidence on how dietary components affect epigenetic mechanisms relevant to cancer.
Comprehensive review of mechanistic, epidemiologic, and translational findings.
Focus on dietary bioactives including polyphenols, isoflavones, and gut microbiome metabolites.
Analysis of their effects on DNA methylation and histone modifications.
Dietary patterns high in cruciferous vegetables and omega-3 fatty acids correlate with reduced cancer incidence.
Bioactive compounds inhibit DNA methyltransferases and promote tumor-suppressive transcriptional states.
High intake of red meat and processed foods is associated with oxidative stress and epigenetic dysregulation.

Cite This Study

Boroomand et al. (2026) studied this question.

synapsesocial.com/papers/6a323d23d50b63ecad206e28 https://doi.org/10.1186/s12986-026-01147-8

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The nutrigenomic-epigenetic axis in cancer: from dietary bioactives to precision oncology

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Implication

Key Points

Cite This Study

The nutrigenomic-epigenetic axis in cancer: from dietary bioactives to precision oncology

Discussion

Member takes

Implication

Key Points

Cite This Study

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