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June 17, 2026Inflammation and RegenerationOpen Access

Modeling striatal development and disease with human pluripotent stem cells

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Authors

SSSopak SupakulYSYuya SasakiKKKosuke Karasawa

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Overview

This review explores human pluripotent stem cells to model striatal development and neurological diseases, indicating significant advancements.

Key Points

  • The aim is to understand human striatal development and pathology using pluripotent stem cells.
  • Summarized approaches for generating striatal cell types from human pluripotent stem cells.
  • Discussed differentiation strategies such as small molecule patterning and three-dimensional organoids.
  • Reviewed disease modeling applications primarily focusing on Huntington’s disease.
  • Identified abnormal developmental, transcriptional, and synaptic features in Huntington's disease models.
  • Showcased efficiency improvements in PSC-derived striatal models through advanced differentiation techniques.
  • Highlighted the potential for circuit-level analyses using cortico-striatal assembloids.

Cite This Study

Supakul et al. (2026) studied this question.

synapsesocial.com/papers/6a323d23d50b63ecad206e7ehttps://doi.org/10.1186/s41232-026-00428-2
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Also Consider

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  1. 1Epigenetic memory of Lateral Ganglionic Eminence derived hiPSCs cannot overcome barriers in authentic MSN differentiation2024
  2. 2Development of a Human iPSC-Derived "Corticospinal Tract-on-a-Chip" for Neurodegenerative Disease Research2025
  3. 3Human Induced Pluripotent Stem Cell-Based Models for Studying Neural Repair2026 · 1 citations
  4. 4Transplanted human striatal progenitors exhibit functional integration and modulate host circuitry in a Huntington’s disease animal model2025
  5. 5Construction of human 3D striato-nigral assembloids to recapitulate medium spiny neuronal projection defects in Huntington’s disease2024 · 35 citations