What question did this study set out to answer?

This research aims to explore how congenital cytomegalovirus infection shapes γδ T cell responses in neonates.

Congenital cytomegalovirus infection drives oligoclonal expansion of cytotoxic γδ T cells from early fetal progenitors

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Randomized trial analyzes antiviral defense in neonates with congenital cytomegalovirus infection, suggesting critical immune responses.

This research aims to explore how congenital cytomegalovirus infection shapes γδ T cell responses in neonates.
Analyzed γδ T cells from cCMV+ and uninfected neonates in Uganda using flow cytometry and paired single-cell RNA and TCR sequencing.
Focused on Vδ1 T cell expansion and differentiation after congenital cytomegalovirus infection.
In cCMV+ neonates, γδ T cells clonally proliferate and differentiate into a uniform population of cytotoxic effectors.
γδ TCR repertoires in cCMV+ infants show shorter CDR3 lengths and fewer N additions compared to uninfected infants, indicating a fetal origin.
Most cells with fetal γδTCR characteristics in cCMV+ infants are effector-differentiated, while they are rare in uninfected infants.

Levan et al. (2026) studied this question.

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