What question did this study set out to answer?

To explore the biological role of pepsin in vocal fold leukoplakia and its clinical implications.

Pepsin in Vocal Fold Leukoplakia: Pathobiological Role, Diagnostic Value, and Therapeutic Implications

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Review summarizes pepsin's role in vocal fold leukoplakia, suggesting potential diagnostic and therapeutic uses.

To explore the biological role of pepsin in vocal fold leukoplakia and its clinical implications.
Conducted a PRISMA-informed review using a PICO framework.
Reviewed literature across multiple databases until March 2026.
Evaluated evidence quality using the GRADE framework.
Pepsin may act as a marker for reflux exposure and a mediator of epithelial injury.
Increased pepsin expression correlates with higher dysplasia severity in vocal fold lesions.
Standard diagnostic approaches remain inconsistent without established pepsin measurement protocols.

Jiang et al. (2026) studied this question.

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