Novel drug delivery system and formulation research are oriented towards increasing safety and efficacy of existing drug molecule through novel concepts of drug delivery. Aceclofenac was formulated as an fast dissolving tablet as there is a need to develop a formulation for this drug which overcomes problem such as difficulty in swallowing, inconvenience in administration while traveling and better compliance. Aceclofenac Fast dissolving tablets were prepared by coprocessed method and different concentration of coprocessed super disintegrants like Polyplasdone XL and Solutab. A total of 10 formulations were prepared and evaluated for various pre and post compression parameters like angle of repose, bulk density, tapped density, carr’s index, hausner’s ratio, weight variation, hardness, friability, thickness, drug content, in vitro disintegration time, in vitro drug release. Among all the ten formulations F10 containing 40 mg of CP5 (Polyplasdone XL: Solutab 2:1) showed maximum drug release in within 15 mins due to less disintegration time. FTIR studies showed good compatibility between drug and excipients.
Hariom Kumar Jha*1, Satyam Kumar Jha2, Ravi Kumar Singh3, Rahul Kumar4, Prince Kumar5, J. Praveen Kumar6 (Tue,) studied this question.