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June 17, 2026MusclesOpen Access

Nicotinamide Riboside Supplementation Protects Against Heat-Induced Skeletal Muscle Injury in Female Mice

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Authors

YCYifan ChenTYTianzheng Yu

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Overview

Randomized trial demonstrates that NAD+ precursor nicotinamide riboside prevents muscle injury in female mice, indicating protective benefits against heat stress.

Key Points

  • The central aim is to assess if nicotinamide riboside (NR) supplementation protects against heat-induced skeletal muscle injury in female mice.
  • Female 6-week-old C57BL/6J mice were orally administered vehicle or NR at 185 mg/kg for 10 days.
  • Following supplementation, mice were exposed to sham or heat stimulation.
  • Evaluations included inflammation, oxidative stress, mitochondrial function, and apoptosis in skeletal muscle.
  • Heat exposure led to significantly lower muscle magnesium (Mg2+) levels compared to sham groups.
  • NR treatment significantly reduced inflammation, oxidative stress, mitochondrial impairment, and apoptosis in skeletal muscle following heat exposure.
  • Heat exposure did not alter muscle NAD+ homeostasis, nor did NR influence NAD+ levels.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a323ed9d50b63ecad207f71https://doi.org/10.3390/muscles5020044
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