Key result
Surgical resection of rare adrenal Castleman disease resolves symptoms with no recurrence at 12 months.
Why the study?
Adrenal involvement in Castleman disease is exceptionally uncommon and poses a significant diagnostic challenge by mimicking primary adrenal neoplasms.
Case Report (n=1)
No
Unicentric hyaline vascular Castleman disease can rarely present as an adrenal mass mimicking a primary adrenal neoplasm, and surgical excision is both diagnostic and curative.
Supports inclusion of Castleman disease in adrenal mass differentials; hypothesis-generating for diagnostic strategies in rare unicentric cases.
Castleman disease (CD) is an uncommon lymphoproliferative disorder of undetermined origin, also known as giant lymph node hyperplasia or angiofollicular lymph node hyperplasia. It is broadly classified into unicentric and multicentric forms, each exhibiting distinct clinical manifestations, pathological features, and prognostic implications. While the mediastinum remains the most frequently involved site, CD may occur in a variety of nodal and extranodal locations. Adrenal involvement is exceptionally uncommon and can pose a significant diagnostic challenge by mimicking primary adrenal neoplasms. We report the case of a 24-year-old man who presented with nonspecific abdominal symptoms and was found to have a right adrenal mass. The patient underwent adrenalectomy, initially via a laparoscopic approach, which was subsequently converted to open surgery because of dense adhesions and proximity to major vascular structures. Histopathological examination established the diagnosis of unicentric hyaline vascular CD involving the adrenal region. To the best of our knowledge, this represents the first reported case of adrenal CD from Myanmar.
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Han et al. (2026) conducted a case report in Unicentric Adrenal Castleman Disease (n=1). Surgical resection (Adrenalectomy) was evaluated on Disease recurrence. Surgical resection of a rare unicentric hyaline vascular Castleman disease presenting as an adrenal mass resulted in complete symptom resolution and no disease recurrence at 12 months.
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