Key result
Advanced ultrasound imaging enables comprehensive assessment of fetal biventricular coupling impaired by congenital heart disease.
Why the study?
Pathological changes such as congenital heart disease and premature ductus arteriosus closure impair fetal biventricular coupling, warranting further exploration into evaluating fetal biventricular coupling status.
Advanced ultrasound imaging techniques offer new perspectives for evaluating fetal biventricular coupling, highlighting the need to establish normal reference criteria and correlate them with perinatal outcomes.
Advanced ultrasound may aid fetal biventricular assessment in CHD; leaves open normal references and perinatal outcome correlations.
The cardiovascular system is among the earliest functional systems in fetal development, playing a central role in maintaining circulation and ensuring oxygen and nutrient delivery. The fetal heart undergoes continuous maturation in anatomical configuration, hemodynamics, and biventricular coupling throughout gestation. Recent advances in ultrasound imaging-including Doppler, tissue doppler imaging (TDI), and two- and three-dimensional speckle tracking-have enabled comprehensive assessment of fetal cardiac structure and function. In addition, emerging techniques such as fetal heart quantification and multimodal imaging, along with artificial intelligence-based approaches, may offer new perspectives for evaluating ventricular coupling. This review indicates that pathological changes such as congenital heart disease (CHD) and premature closure of the ductus arteriosus can lead to fetal cardiac structural abnormalities and hemodynamic disturbances. Based on the core mechanism of biventricular decoupling in adults, these changes form the pathophysiological basis for impaired fetal biventricular coupling. Accordingly, further exploration is warranted for the evaluation of fetal biventricular coupling status. Subsequent studies should first establish its normal reference criteria and clarify the correlation between this indicator and perinatal outcomes.
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方文伶 et al. (2026) conducted a review in Fetal cardiac structural abnormalities and hemodynamic disturbances. Ultrasound imaging was evaluated. Advanced ultrasound imaging techniques enable comprehensive assessment of fetal biventricular coupling, which is impaired by conditions like congenital heart disease and requires further exploration.
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