Key result
Women with a history of adverse pregnancy outcomes and signs of ischemia without obstructive coronary artery disease had significantly lower coronary flow reserve compared to those without such history (2.53 vs. 2.76, p=0.016).
Why the study?
It was hypothesized that women with CMD and signs and symptoms of ischemia without obstructive CAD are more likely to have a history of adverse pregnancy outcomes.
Does a history of adverse pregnancy outcomes associate with reduced coronary flow reserve in women with signs and symptoms of ischemia without obstructive CAD?
Population
324 women with signs and symptoms of ischemia without obstructive CAD
Comparison
History of any APO vs no APO
Design
Cohort study
Authors
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History of APO linked to lower CFR in women with INOCA; supports microvascular dysfunction hypothesis but should not yet change practice.
Observational (n=324)
Yes
Does a history of adverse pregnancy outcomes associate with reduced coronary flow reserve in women with signs and symptoms of ischemia without obstructive CAD?
Absolute Event Rate: 2.53% vs 2.76%
p-value: p=0.016
A history of adverse pregnancy outcomes is associated with reduced coronary flow reserve, suggesting a link between pregnancy complications and the later development of coronary microvascular dysfunction.
Park et al. (2019) conducted an observational in Signs and symptoms of ischemia without obstructive coronary artery disease (n=324). History of adverse pregnancy outcomes vs. No history of adverse pregnancy outcomes was evaluated on Coronary flow reserve (CFR) (p=0.016). Women with a history of adverse pregnancy outcomes and signs of ischemia without obstructive coronary artery disease had significantly lower coronary flow reserve compared to those without such history (2.53 vs. 2.76, p=0.016).
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