Statistical tests using public cross-species and clinical data supported the corollary of the passive predetermination of the heart as a dissipation center.
Proposes a unifying physical framework explaining nine core observational facts of cardiac physiology, supported by statistical tests on public cross-species and clinical data.
Cardiac physiology has accumulated nine core observational facts—necessity of pulsation, sinoatrial node autonomous pacing, all-or-none action potential, topological differentiation of arteries and veins, near-absence of cardiomyocyte division, heart failure with preserved ejection fraction, tachycardia-induced heart failure, age-dependent decline in maximum heart rate, and irreversible progression of atrial fibrillation. These facts are currently dispersed across different chapters of electrophysiology, hemodynamics, and pathophysiology. This paper proposes that they can be uniformly explained within a single physical framework: the heart is the dissipation center geometrically predetermined at the very moment of energy injection in a multicellular aggregate. This paper uses three categories of independent public data—cross-species embryogenesis timeline, clinical data of birth circulatory transition, and cross-species allometric scaling data—to conduct independent statistical tests on the above corollary. All test results support the corollary of the passive predetermination of the heart. All tests use publicly available data and standard statistical methods and can be independently reproduced by any researcher. This paper presupposes no biological theory and only conducts statistical tests on public data.
Menggang Yu (Wed,) conducted a other in Cardiac physiology. Passive predetermination of the heart framework was evaluated. Statistical tests using public cross-species and clinical data supported the corollary of the passive predetermination of the heart as a dissipation center.