Statistical tests of cross-species embryogenesis, birth transition, and allometric scaling data supported the corollary of the passive predetermination of the heart.
Statistical analysis of public biological and clinical data supports a novel theoretical framework proposing the heart as a passively predetermined dissipation center rather than an actively evolved pump.
This paper tests a physical corollary: the heart is not a pump actively designed by evolution, but the dissipation center geometrically predetermined at the very moment of energy injection in a multicellular aggregate. Three independent categories of public data are used for independent statistical tests—cross-species embryogenesis timeline, clinical data of birth circulatory transition, and cross-species allometric scaling data. Cardiac physiology has accumulated nine core observational facts—necessity of pulsation, sinoatrial node autonomous pacing, all-or-none action potential, topological differentiation of arteries and veins, near-absence of cardiomyocyte division, heart failure with preserved ejection fraction, tachycardia-induced heart failure, age-dependent decline in maximum heart rate, and irreversible progression of atrial fibrillation. These facts are currently dispersed across different chapters of electrophysiology, hemodynamics, and pathophysiology. All test results support the corollary of the passive predetermination of the heart. All tests use publicly available data and standard statistical methods and can be independently reproduced by any researcher. This paper presupposes no biological theory and only conducts statistical tests on public data.
Menggang Yu (Fri,) reported a other. Statistical tests of cross-species embryogenesis, birth transition, and allometric scaling data supported the corollary of the passive predetermination of the heart.