Khat chewing and bladder neck dysfunction. A randomized controlled trial of α ₁ ‐adrenergic blockade

Objective To assess whether the effect of chewing khat leaves ( Catha edulis ) on the urodynamics of healthy males is altered by the selective α 1 ‐adrenergic blocking agent indoramin in a prospective randomized double‐blind controlled trial. Subjects and methods The urodynamics of 11 healthy males were studied before and during a khat chewing session preceded by indoramin or placebo. Results Khat chewing produced a fall in average and maximum urine flow rate. This effect was inhibited by indoramin. Conclusions The urinary side‐effects of khat chewing are probably mediated through stimulation of α 1 adrenergic receptors. Keywords Khat, Catha edulis , α 1 adrenergic blocker, indoramin, urodynamics.