What question did this study set out to answer?

To investigate histological and neuroanatomical changes in bladder innervation induced by partial bladder outlet obstruction in a rat model.

December 1, 1998British Journal of Urology

Neuroanatomical changes in the rat bladder after bladder outlet obstruction

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Authors

SSutherlandUniversity of East Anglia BBaskin KKogan

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Implication

Controlled animal study reveals cholinergic and adrenergic nerve remodeling in obstructed female rats, indicating structural neuropathic changes drive bladder dysfunction.

Key Points

To investigate histological and neuroanatomical changes in bladder innervation induced by partial bladder outlet obstruction in a rat model.
Partial bladder outlet obstruction was surgically induced in 48 adult female rats by ligating the proximal urethra over a 20 G angiocatheter, compared against 18 sham-operated controls.
Bladders were collected at 1, 2, and 4 weeks post-surgery for computerized morphometric analysis, cystometry, and staining for protein gene-product 9.5, acetylcholinesterase, adrenergic fibers, and nitric oxide synthase.
Obstruction induced a six- to sevenfold increase in bladder volume and weight with early and sustained smooth muscle hypertrophy across all time points.
Cystometry demonstrated elevated bladder capacities and increased voiding pressures reaching 80–100 cmH2O in obstructed rats compared to 30–40 cmH2O in controls.
Histochemical analyses showed marked reductions in cholinergic and adrenergic nerve staining within and around smooth muscle bundles, a slight increase in protein gene-product 9.5 immunoreactivity, and an unaltered L-arginine-nitric oxide pathway.

Cite This Study

Sutherland et al. (1998) studied this question.

synapsesocial.com/papers/6a7742ea0c6965f1a01ea9f8 https://doi.org/10.1046/j.1464-410x.1998.00873.x

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Implication

Controlled animal study reveals cholinergic and adrenergic nerve remodeling in obstructed female rats, indicating structural neuropathic changes drive bladder dysfunction.

Neuroanatomical changes in the rat bladder after bladder outlet obstruction

Discussion

Member takes

Implication

Key Points

Cite This Study

Neuroanatomical changes in the rat bladder after bladder outlet obstruction

Discussion

Member takes

Implication

Key Points

Cite This Study

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