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This study aims to investigate the effectiveness of hollow gold nanospheres for imaging and treating glioma through photothermal ablation.

August 20, 2011Cancer ResearchOpen Access

Effects of Photoacoustic Imaging and Photothermal Ablation Therapy Mediated by Targeted Hollow Gold Nanospheres in an Orthotopic Mouse Xenograft Model of Glioma

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Randomized trial demonstrates improved survival in glioma using photoacoustic imaging and treatment.

This study aims to investigate the effectiveness of hollow gold nanospheres for imaging and treating glioma through photothermal ablation.
Used photoacoustic tomography for imaging hollow gold nanospheres targeted to glioma integrins.
Mice treated with near-infrared laser to induce photothermal ablation resulting in a temperature increase of 20.7°C.
Evaluated survival outcomes of tumor-bearing mice following treatment.
PTA treatment significantly prolonged survival of tumor-bearing mice (specific metrics not provided).

Lü et al. (2011) studied this question.

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