Meta-analysis assesses dose rate definitions for FLASH sparing effect in skin, indicating average dose rate as crucial.
We compiled preclinical proton PBS skin toxicity data to assess how various dose rate definitions (field, average, and dose average) explain the FLASH sparing effect. Only average dose rate (ADR), accounting for 'effective irradiation time,' reliably describes it. We identified high-dose and ADR regions where the effect was consistently observed.
No takes yet. Share an insight, caveat, or question.
Colizzi et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: