Key result
Higher TyG index linked to ~72% greater CVD risk in non-malnourished patients, but U-shaped if malnourished.
Why the study?
Blood glucose and lipids are affected by nutritional status, but few studies have explored whether the association between the TyG index and CVD risk varies by nutritional status.
Does the triglyceride-glucose (TyG) index associate with the prevalence of cardiovascular disease differently in malnourished versus non-malnourished populations?
Cross-Sectional (n=19,847)
Does the triglyceride-glucose (TyG) index associate with the prevalence of cardiovascular disease differently in malnourished versus non-malnourished populations?
Odds Ratio: 1.72 (95% CI 1.31–2.25)
p-value: p=<0.001
The association between the TyG index and cardiovascular disease risk varies by nutritional status, exhibiting a U-shaped curve in malnourished patients, which highlights the need to consider nutritional status when using TyG for CVD risk stratification.
Associated with higher CVD odds; leaves open causal inference and clinical utility in cross-sectional data.
Background Numerous investigations have demonstrated a strong association between the TyG (triglyceride-glucose) index, which is derived from lipid and glucose levels in the bloodstream, and the onset and progression of cardiovascular diseases (CVD). Blood glucose and blood lipids are affected by nutritional status, and few studies have explored whether the correlation between TyG index and the risk of CVD is affected by nutritional status. Aims To investigate the connection between TyG index and the risk of CVD among individuals with varying nutritional statuses. Method A total of 19,847 were included in the analysis, of which 15,955 participants were non-malnourished and 3,892 patients were malnourished. According to the TyG index quartile, the patients were categorized into four groups. Logistic regression analysis and restricted cubic spline was used to study the relationship between TyG index and the risk of CVD in normal and malnourished populations. Results The results of the restricted cubic spline showed that the TyG index was positively associated with the risk of CVD in the non-malnourished population. The TyG index showed a U-shaped association with the risk of CVD in malnourished people. The result is consistent with that of logistic regression (Malnutrition: Group 2: OR: 1.14; 95% CI: 0.85–1.53; Group 3: OR: 1.36; 95% CI: 1.03–1.79; Group 4: OR: 1.72; 95% CI:1.31–2.25, P for trend <0.001; Non-malnutrition: Group 2: OR: 0.82; 95% CI: 0.46–1.48; Group 3: OR: 0.88; 95% CI: 0.49–1.57; Group 4: OR: 1.45; 95% CI:0.83–2.52, P for trend =0.067). Conclusions The association between the TyG index and the risk of CVD varied depending on the nutritional states. When using TyG index to assess the risk of CVD, stratification combined with nutritional status helps to more accurately screen patients at high risk of CVD.
No takes yet. Share an insight, caveat, or question.
Jiang et al. (2023) conducted a cross-sectional in Cardiovascular disease (n=19,847). Triglyceride-glucose (TyG) index vs. Lowest TyG index quartile was evaluated on Prevalence of cardiovascular disease (CVD) (OR 1.72, 95% CI 1.31-2.25, p=<0.001). A higher triglyceride-glucose index was positively associated with cardiovascular disease risk in non-malnourished individuals (OR 1.72), whereas it showed a U-shaped association in malnourished patients.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: