Key result
A very high cumulative triglyceride-glucose index was associated with a 59% increased risk of major adverse cardiovascular events compared to a low index in patients with type 2 diabetes (HR 1.59).
Why the study?
The long-term effect of the triglyceride-glucose index on the incidence of MACEs in patients with T2DM remained unclear.
Does a higher cumulative TyG index predict an increased risk of MACEs in patients with type 2 diabetes?
Population
5695 patients with T2DM without prior MACEs from the ACCORD trial
Comparison
Higher vs lower cumulative TyG index quartiles
Design
Post-hoc analysis of a randomized trial
Follow-up
Median 5.09 years
Authors
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Cumulative TyG index may refine long-term MACE risk assessment in T2DM; extends single-measure data but leaves clinical adoption open.
Cohort (n=5,695)
Yes
Does a higher cumulative TyG index predict an increased risk of MACEs in patients with type 2 diabetes?
Hazard Ratio: 1.59 (95% CI 1.17–2.16)
Absolute Event Rate: 14.13% vs 9.27%
p-value: p=0.003
The cumulative TyG index is an independent predictor of MACEs in patients with type 2 diabetes, offering incremental predictive value over conventional risk models.
Tai et al. (2022) conducted a cohort in Type 2 diabetes mellitus (n=5,695). Cumulative triglyceride-glucose (TyG) index vs. Low cumulative TyG index quartile (< 34.86) was evaluated on Major adverse cardiovascular events (MACEs), including non-fatal MI, non-fatal stroke, and CVD-related death (HR 1.59, 95% CI 1.17-2.16, p=0.003). A very high cumulative triglyceride-glucose index was associated with a 59% increased risk of major adverse cardiovascular events compared to a low index in patients with type 2 diabetes (HR 1.59).
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